|Confidants||Medulla and Oblongata (henchmen)|
Sergeant Mike Cosgrove
Yakko and Wakko Warner
|First appearance||"Freakazoid and Friends"|
|Voiced by||David Warner|
The Lobe is Freakazoid's archenemy. He is also a super genius because he has a very huge brain. Despite his intellect, he has very low self-esteem. He also has henchmen, their names are Medulla and Oblongata. No background information of his past, or any kind is given for The Lobe; not even his real name is real name is revealed. The Lobe also goes to the Washington Gardens alot to eat.