Scooby-Doo was a Hanna-Barbera animated series that was originally produced for Saturday morning television. Debuting in 1969 on CBS, the characters have appeared in numerous spin-offs and versions, as well as direct-to-video movies and prime-time specials. Beginning in 1998, Warner Bros. Animation took over production of the animated Scooby-Doo franchise.
- In Looney Tunes: Back in Action, Scooby-Doo and Shaggy Rogers makes a cameo at the studio lunchroom, criticizing Matthew Lillard for his portrayal of Shaggy in the live-action Scooby-Doo film. (Ironically, Lillard would eventually become Shaggy's official voice actor in 2010.)
- The Big Game XXIX: Bugs Vs. Daffy - At the beginning of the pregame show, a clip is shown in which Jerry Glanville predicts that the Big Game would be Thundarr the Barbarian vs. Scrappy-Doo. During the game itself, Pat Summerall remarks that adding Scrappy to Scooby-Doo was one of the worst business decisions ever made, and later, John Madden comments that the game "is becoming as repetitive as Scooby-Doo!"
- "Return to China" - After getting Huang Di's autograph, Pepper Mills responds, "Hey, you're not Scooby-Doo! Gypola!"
- At the beginning of the What's New Scooby-Doo? episode "New Mexico, Old Monster", Scooby sees one of Wile E. Coyote's attempts to catch the Road Runner and is confused by this sight.