Family Guy is a adult animaded TV comedy series created by Seth Macfarlene.

The show has done many parodoy's of Looney Tunes

In I Never Met the Dead Man, Wile E. Coyote is seen riding in a car with Peter, runs over the Road Runner. When Peter realizes it, tells him to keep going.

In "PTV", Coyote appears in a cutaway when Peter claims he worked for ACME. He offers a store credit when Wile E. claims a refund for a giant sling shot that slammed him into a mountain. Mrs. Coyote then appears telling her husband to hurry up.

Foghorn Leghorn visits a KFC in Back to the Woods. He greets Colonel Sanders complimenting the smells of the spices. Sanders then decapitates him with a meat cleaver. Leghorn watches his headless body run around with guidance, not realizing his head was cut off until mid-sentence.

Bugs Bunny and Elmer Fudd have a showdown in Stewie Griffin: The Untold Story. Bugs is shot in the chest by Fudd, followed by Fudd snapping his neck, instantly killing him and ending their rivalry.

In E. Peterbus Unum, Peter Griffin's grandfather, Osias Griffin, a Warner Bros. animator, recommended naming Bugs Bunny "Ephraim the Retarded Rabbit", a name no other worker agreed with.

Rapid Dave is the American equivalent of Speedy Gonzales. He was created by Peter in "Padre de Familia" as a way of cleansing children's entertainment of foreign characters. Sylvester the Cat is seen chasing Dave before he escapes.

Yosemite Sam is fitted for extremely tight pants in Tales of a Third Grade Nothing.

Partial Terms of Endearment features an extended parody of the Road Runner cartoons as Peter tries to force his wife Lois to have an abortion.

Luke Skywalker, played by Chris Griffin, has a typical Wile E. Coyote fall during his duel with Darth Vader, played by Stewie Griffin, in Something, Something, Something, Dark Side. He holds up a "HELP" sign, and then his body from the neck down droops before his whole body falls.

Seth MacFarlane's Cavalcade of Cartoon Comedy includes a short entitled "Die, Sweet Roadrunner, Die," in which Wile E. Coyote finally kills and eats the Road Runner, but then realizes that he doesn't know what to do with his life now.

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